[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
Main Menu
Journal Information::
Articles Archive::
Guide for Authors::
For Reviewers::
Ethical Statements::
Site Facilities::
Contact us::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
Copyright Policies




Open Access Policy

This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

:: Volume 11, Issue 3 (Summer 2023) ::
Shefaye Khatam 2023, 11(3): 81-94 Back to browse issues page
A Review of the Therapeutic Effects of Natural Antioxidant Compounds on the Improvement of Autism Spectrum Disorder
Maryam Faghih Neiresy , Akbar Hajizadeh moghaddam * , Sedigheh Khanjani jelodar , Ehsan Nazifi , Farshad Sohbatzadeh Lonbar
Department of Animal Science, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran , a.hajizadeh@umz.ac.ir
Abstract:   (919 Views)
Introduction: Autism spectrum disorder (ASD) is a progressive multifactorial neurological disease. This disease can be diagnosed before the age of 3 with behavioral disorders. Repetitive and stereotyped behaviors, social interaction disorders, and verbal abnormalities are among the prominent diagnostic features of autism. ASD may be caused by disruptions in the synaptic transmission of different parts of the brain, such as the cerebellum, hippocampus, basal ganglia, amygdala, and prefrontal cortex. In an autistic person, the dynamic imbalance between reactive oxygen species and reactive nitrogen species reduces the antioxidant defense. This can be one of the causes of synaptic disorders between neurons in different parts of the brain. The body responds to oxidative stress with its antioxidant defense system. However, reduced defense capacity or disruption of physiological processes may result in inappropriate responses of the immune system. Recent investigations revealed that the administration of natural antioxidant compounds, such as carotenoids, vitamin C, flavonoids, phenols, and selenium, could increase the antioxidant balance and improve behaviors in ASD. Conclusion: Considering the significant role of oxidative stress in tissue damage and the pathophysiology of ASD, using antioxidant compounds could be a useful approach to promote synaptic plasticity in different brain regions and improve ASD symptoms.

Keywords: Autism Spectrum Disorder, Social Interaction, Antioxidants
Full-Text [PDF 1357 kb]   (578 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Neurology
1. Barak B, Feng G. Neurobiology of social behavior abnormalities in autism and Williams syndrome. Nat Neurosci J. 2016; 19(5): 647-55. [DOI:10.1038/nn.4276]
2. O'Brien G, Pearson J. Autism and learning disability. Autism J. 2004; 8(2): 125-40. [DOI:10.1177/1362361304042718]
3. Crespi BJ. Autism, psychosis, and genomic imprinting: recent discoveries and conundrums. Curr Opin Behav Sci J. 2019; 1(25): 1-7. [DOI:10.1016/j.cobeha.2018.05.008]
4. D'Mello AM. CatherineJ.Stoodley. Cerebro-cerebellarcircuitsinautismspectrumdisorder. Front Neurosci J. 2015; 5(9): 408. [DOI:10.3389/fnins.2015.00408]
5. Hajisoltani R, A. KS, Rahdar M, Davoudi S, Borjkhani M, Hosseinmardi N. Hyperexcitability of hippocampal CA1 pyramidal neurons in male offspring of a rat model of autism spectrum disorder (ASD) induced by prenatal exposure to valproic acid: a possible involvement of Ih channel current. Brain Res J. 2019; 1(1708): 188-99. [DOI:10.1016/j.brainres.2018.12.011]
6. Thabault M, Turpin V, Maisterrena A, Jaber M, Egloff M, Galvan L. Cerebellar and Striatal Implications in Autism Spectrum Disorders: From Clinical Observations to Animal Models. Int J Mol Sci J. 2022; 23(4): 2294. [DOI:10.3390/ijms23042294]
7. Olexová L, Stefánik P, Krˇsková L. Increased anxiety-like behaviour and altered GABAergic system in the amygdala and cerebellum of VPA rats - An animal model of autism. Neurosci Lett J. 2016; 26(629): 9-14. [DOI:10.1016/j.neulet.2016.06.035]
8. Xu P, Chen A, Li Y, Xing X, Lu H. The medial prefrontal cortex in neurological diseases. Physiol Genomics J. 2019; 51(9): 432-42. [DOI:10.1152/physiolgenomics.00006.2019]
9. Schuetze M, Park MTM, Cho LYK, MacMaster FP, Chakravarty MM, Bray SL. Morphological Alterations in the Thalamus, Striatum, and Pallidum in Autism Spectrum Disorder. Neuropsychopharmacology J. 2016; 41(11): 2627-37. [DOI:10.1038/npp.2016.64]
10. Gjika E, Pal-Ghosh S, Tang A, Kirschner M, Tadvalkar G, Canady J, et al. Adaptation of operational parameters of cold atmospheric plasma for in vitro treatment of cancer cells. ACS J. 2018; 10(11): 9269-79. [DOI:10.1021/acsami.7b18653]
11. Abuaish S, Al-Otaibi NM, Abujamel TS, Alzahrani SA, Alotaibi AM, AlShawakir YA, et al. Fecal Transplant and Bifidobacterium Treatments Modulate Gut Clostridium Bacteria and Rescue Social Impairment and Hippocampal BDNF Expression in a Rodent Model of Autism. Brain Sci J. 2021; 11(8): 1038. [DOI:10.3390/brainsci11081038]
12. McConnell SR. Interventions to Facilitate Social Interaction for Young Children with Autism: Review of Available Research and Recommendations for Educational Intervention and Future Research. JADD. 2002; 32: 351-72.
13. Stoodley CJ, Schmahmann JD. Functional topography in the human cerebellum: A meta-analysis of neuroimaging studies. NEIM J. 2009; 44(2): 489-501. [DOI:10.1016/j.neuroimage.2008.08.039]
14. Strick PL, Dum RP, Fiez JA. Cerebellum and nonmotor function. Annu Rev Neuro sci J. 2009; 32: 413-34. [DOI:10.1146/annurev.neuro.31.060407.125606]
15. Morakotsriwan N, Wattanathorn J, Kirisattayakul W, Chaisiwamongkol K. Autistic-Like Behaviors, Oxidative Stress Status, and Histopathological Changes in Cerebellum of Valproic Acid Rat Model of Autism Are Improved by the Combined Extract of Purple Rice and Silkworm Pupae. Oxid Med Cell Longevity J. 2016; 10. [DOI:10.1155/2016/3206561]
16. Hajizadeh Moghaddam A, Eslami A, khanjani Jelodar S, Ranjbar M, Hasantabar V. Preventive effect of quercetin-Loaded nanophytosome against autistic-like damage in maternal separation model: The possible role of Caspase-3, Bax/Bcl-2 and Nrf2. Behav Brain Res J. 2023; 12: 114300. [DOI:10.1016/j.bbr.2023.114300]
17. Hoher Camargo SP, Rispoli M, Ganz J, Hong ER, Davis H, Mason R. A Review of the Quality of Behaviorally-Based Intervention Research to Improve Social Interaction Skills of Children with ASD in Inclusive Settings. JADD. 2014; 44: 2096-116. [DOI:10.1007/s10803-014-2060-7]
18. Li W, Pozzo-Miller L. Dysfunction of the corticostriatal pathway in autism spectrum disorders. JNR. 2020; 98(11): 2130-47. [DOI:10.1002/jnr.24560]
19. Huang T-T, Leu D, Zou Y. Oxidative stress and redox regulation on hippocampal-dependent cognitive functions. ABB J. 2015; 576: 2-7. [DOI:10.1016/j.abb.2015.03.014]
20. Pavăl D. A Dopamine Hypothesis of Autism Spectrum Disorder. Dev Neurosci J. 2017; 39(5): 355-60. [DOI:10.1159/000478725]
21. Silveira de Mattos BD, Pereira Soares MS, Spohr L, Pedra NS, Teixeira FC, Avila de Souza A, et al. Quercetin prevents alterations of behavioral parameters, delta-aminolevulinic dehydratase activity, and oxidative damage in brain of rats in a prenatal model of autism. ISDN J. 2020; 80(4): 287-302. [DOI:10.1002/jdn.10025]
22. Bellani M, Calderoni S, Muratori F, Brambilla P. Brain anatomy of autism spectrum disorders II. Focus on amygdala. EPS J. 2013; 22(4): 309-12. [DOI:10.1017/S2045796013000346]
23. Salim S. Oxidative Stress and the Central Nervous System. JPET. 2017; 360(1): 201-5. [DOI:10.1124/jpet.116.237503]
24. Frith U, Happe F. Autism: beyond "theory of mind". Cogn J. 1994; 50(1-3): 115-32. [DOI:10.1016/0010-0277(94)90024-8]
25. Dichter GS. Functional magnetic resonance imaging of autism spectrum disorders. DCNS J. 2022; 14(3): 319-51. [DOI:10.31887/DCNS.2012.14.3/gdichter]
26. Murdaugh DL, Shinkareva SV, Deshpande HR, Wang J, Pennick MR, Kana RK. Differential Deactivation during Mentalizing and Classification of Autism Based on Default Mode Network Connectivity. PLOS ONE J. 2012; 7(11): e50064. [DOI:10.1371/journal.pone.0050064]
27. Baroncelli L, Braschi C, Spolidoro M, Begenisic T, Maffei L, Sale A. Brain Plasticity and Disease: A Matter of Inhibition. Neural Plast J. 2011; 11. [DOI:10.1155/2011/286073]
28. Gogolla N, Takesian AE, Feng G, Fagiolini M, Hensch TK. Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation. Neuron J. 2014; 83(4): 894-905. [DOI:10.1016/j.neuron.2014.06.033]
29. Peça J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, et al. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nat J. 2011; 472(7344): 437-42. [DOI:10.1038/nature09965]
30. Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O'Shea DJ, et al. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nat J. 2011; 477(7367): 171-8. [DOI:10.1038/nature10360]
31. Nelson SB, Valakh V. Excitatory/inhibitory balance and circuit homeostasis in autism spectrum disorders. Neuron J. 2015; 87(4): 684-98. [DOI:10.1016/j.neuron.2015.07.033]
32. Taleb A, Lin W, Xu X, Zhang G, Zhou Q-G, Naveed M, et al. Emerging mechanisms of valproic acid-induced neurotoxic events in autism and its implications for pharmacological treatment. Biomed Pharmacother J. 2021; 137: 111332. [DOI:10.1016/j.biopha.2021.111322]
33. Bölte S, Girdler S, Marschik PB. The contribution of environmental exposure to the etiology of autism spectrum disorder. Cell Mol Life Sci J. 2018; 15(76): 1275-97. [DOI:10.1007/s00018-018-2988-4]
34. Hajizadeh Moghaddam A, Eslami A, khanjani Jelodar S, Ranjbar M, Hasantabar V. Preventive effect of quercetin-Loaded nanophytosome against autistic-like damage in maternal separation model: The possible role of Caspase-3, Bax/Bcl-2 and Nrf2. Behav Brain Res J. 2023; 12: 114300. [DOI:10.1016/j.bbr.2023.114300]
35. Hajizadeh Moghaddam A, Abbasalipour H, Ranjbar M, Khanjani Jelodar S. Effect of Sumac Nano-phytosome on Memory and Oxidative Stress in Valproic Acid-induced Rat Model of Autism Spectrum Disorder. Guil Uni Med Sci J. 2021; 29(4): 102-13. [DOI:10.32598/JGUMS.29.4.950.1]
36. Nabavi SM, Nabavi SF, Eslami S, Hajizadeh Moghaddam A. In vivo protective effects of quercetin against sodium fluoride-induced oxidative stress in the hepatic tissue. Food chem J. 2012; 132(2): 931-5. [DOI:10.1016/j.foodchem.2011.11.070]
37. Nabavi SF, Nabavi SM, Latifi AM, Mirzaei M, Habtemariam S, Hajizadeh Moghaddam A. Mitigating role of quercetin against sodium fluoride-induced oxidative stress in the rat brain. Pharm Biol J. 2012; 50(11): 1380-3. [DOI:10.3109/13880209.2012.675341]
38. Bjørklund G, Meguid NA, El-Bana MA, Tinkov AA, Saad K, Dadar M, et al. Oxidative Stress in Autism Spectrum Disorder. Mol Neurobiol J. 2020; 57: 2314-32. [DOI:10.1007/s12035-019-01742-2]
39. Zarkovic K. 4-Hydroxynonenal and neurodegenerative diseases. Mol Aspects Med J. 2003; 24(4-5): 293-303. [DOI:10.1016/S0098-2997(03)00024-4]
40. Abdel-Salam OME, Youness ER, Mohammed NA, Abu Elhamed WA. Nuclear Factor-Kappa B and Other Oxidative Stress Biomarkers in Serum of Autistic Children. Open J Mol Integr Physiol J. 2015; 5(1): 18-27. [DOI:10.4236/ojmip.2015.51002]
41. Jouve L, Engelmann F, Noirot M, Charrier A. Evaluation of biochemical markers (sugar, proline, malonedialdehyde and ethylene) for cold sensitivity in microcuttings of two coffee species. Plant Sci J. 1993; 91(1): 109-16. [DOI:10.1016/0168-9452(93)90194-5]
42. Soguta S, Zoroglub SS, Ozyurtc H, Yılmazd HR, Ozugurluc F, Sivaslı E, et al. Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism. CCA J. 2003; 331(1-2): 111-7. [DOI:10.1016/S0009-8981(03)00119-0]
43. Gorrindo P, Lane CJ, Lee EB, McLaughlin B, Levitt P. Enrichment of Elevated Plasma F2t-Isoprostane Levels in Individuals with Autism Who Are Stratified by Presence of Gastrointestinal Dysfunction. PLOS ONE J. 2013; 8(7): e68444. [DOI:10.1371/journal.pone.0068444]
44. Cipolla CM, Lodhi IJ. Peroxisomal Dysfunction in Age-Related Diseases. Trends Endocrinol Metab J. 2017; 28(4): 297-308. [DOI:10.1016/j.tem.2016.12.003]
45. Sadat E, Javaheri SJ, Bigdeli MR, Zibaii MI, Dargahi L, Pouretemad HR. Optogenetic Stimulation of the Anterior Cingulate Cortex Ameliorates Autistic-Like Behaviors in Rats Induced by Neonatal Isolation, Caudate Putamen as a Site for Alteration. NeuroMol Med J. 2019; 21: 132-42. [DOI:10.1007/s12017-019-08526-w]
46. khoshnazar M, Farhadi Maghadam B. Neuroprotective Effect of Alpha-Pinene on Focal Cerebral Ischemia in Rats. Shefaye Khatam 2022; 10 (3) :37-47 [DOI:10.52547/shefa.10.3.37]
47. Francenia Santos-Sánchez N, R. S-C, Villanueva-Cañongo C, Hernández-Carlos B. Antioxidant Compounds and Their Antioxidant Mechanism. Antioxidants. 5 ed: IntechOpen; 2019. 23-50 p. [DOI:10.5772/intechopen.85270]
48. Edge R, George Truscott T. Singlet Oxygen and Free Radical Reactions of Retinoids and Carotenoids-A Review. Antioxidants J. 2018; 7(1): 5. [DOI:10.3390/antiox7010005]
49. Viana CE, Bortolotto VC, Machado Araujo SM, Mustafa Dahleh MM, Machado FR, Pereira ADS, et al. Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats. NeuroToxicology J. 2023; 94: 223-34. [DOI:10.1016/j.neuro.2022.12.006]
50. Karimian A, Mir Mohammadrezaei F, Hajizadeh Moghadam A, Bahadori MH, Ghorbani-Anarkooli M, Asadi A, et al. Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines. Acta Histochem J. 2022; 124(1): 151832. [DOI:10.1016/j.acthis.2021.151832]
51. Al-Amin MdM, Rahman MM, Rahman Khan F, Zaman F, Mahmud Reza H. Astaxanthin improves behavioral disorder and oxidative stress in prenatal valproic acid-induced mice model of autism. Behav Brain Res J. 2015; 289: 112-21. [DOI:10.1016/j.bbr.2015.02.041]
52. Li F-J, Shen L, Ji H-F. Dietary Intakes of Vitamin E, Vitamin C, and β-Carotene and Risk of Alzheimer's Disease: A Meta-Analysis. JADD. 2012; 31(2): 253-8. [DOI:10.3233/JAD-2012-120349]
53. Kocot J, Luchowska-Kocot D, Kiełczykowska M, Musik I, Kurzepa J. Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders? Nutrients J. 2017; 9(7): 659. [DOI:10.3390/nu9070659]
54. Aghighi F, Salami M, Talaei A. Effect of Prenatal Stress on Offspring's Learning, Memory and Coping Strategies. Shefaye Khatam 2019; 7 (4) :106-121 [DOI:10.29252/shefa.7.4.106]
55. Yule MS S, Wanik J, Holm EM, Bruder MB, Shanley E, Sherman CQ, et al. Nutritional Deficiency Disease Secondary to ARFID Symptoms Associated with Autism and the Broad Autism Phenotype: A Qualitative Systematic Review of Case Reports and Case Series. J Acad Nutr Diet. 2021; 121(3): 467-92. [DOI:10.1016/j.jand.2020.10.017]
56. Nayan NS, Mohd Yazid MA, Nallappan K, Amran AA, Zaidi NS, Zakaria F, et al. In Vitro Modulation of Endogenous Antioxidant Enzyme Activities and Oxidative Stress in Autism Lymphoblastoid Cell Line (ALCL) by Stingless Bee Honey Treatment. Oxid Med Cell Longev J. 2020; 1-7. [DOI:10.1155/2020/4539891]
57. Pangrazzi L, Balasco L, Bozzi Y. Natural Antioxidants: A Novel Therapeutic Approach to Autism Spectrum Disorders? Antioxidants J. 2020; 9(12): 1186. [DOI:10.3390/antiox9121186]
58. Moradi H R, Taherianfard M, Rashidi M, Javid Z, Hesami S A. Protective Effects of Wheat Sprout on Acrylamide Toxicity in the Hippocampus Structure and Spatial Learning and Memory of Rat. Shefaye Khatam 2023; 11 (2) :10-19
59. Pietta P-G. Flavonoids as Antioxidants. J Nat Prod. 2000; 63(7): 1035-42. [DOI:10.1021/np9904509]
60. Hajizadeh Moghaddam A, Barari R, Khanjani Jelodar S, Hasantabar V. Neuroprotective Effects of Silymarin-Loaded Chitosan Nanoparticles on Ketamine-Induced Cognitive Disorders and Oxidative Damages in Mice Hippocampus. Shefaye Khatam 2022; 10(2): 1-2.
61. Bors W, Heller W, Michel C, Saran M. Flavonoids as Antioxidants: Determination of Radical-Scavenging Efficiencies. Methods Enzymol J. 1998; 186.
62. Khalaj R, Hajizadeh Moghaddam A, Zare M. Hesperetin and it nanocrystals ameliorate social behaviordeficits and oxido-inflammatory stress in rat model of autism. Int J Dev Neurosci. 2018; 69: 80-7. [DOI:10.1016/j.ijdevneu.2018.06.009]
63. Babaei M, Elmi T, Kalantari-Hesari A. Effects of Hydroalcoholic Extract of Malva Sylvestris L. on the Histological Structure of the Brain in a Mice Model of Parkinson's Disease. Shefaye Khatam 2023; 11 (2) :1-9
64. Greeson JM, Sanford B, Monti DA. St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature. Psychopharmacology J. 2001; 153: 402-14. [DOI:10.1007/s002130000625]
65. Khanjani Jelodar S, Bigdeli M, Hajizadeh Moghaddam A. The Effect of Hypericin on Autism Like Behavior in Maternal Separation Animal Model: An Experimental Study. JRUMS. 2020; 19[1]: 569-78. [DOI:10.29252/jrums.19.6.569]
66. Wu H, Zhao G, Liu S, Zhang Q, Wang P, Cao Y, et al. Supplementation with selenium attenuates autism-like behaviors and improves oxidative stress, inflammation and related gene expression in an autism disease model. JNB. 2022; 107: 109034. [DOI:10.1016/j.jnutbio.2022.109034]

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Faghih Neiresy M, hajizadeh moghaddam A, khanjani jelodar S, nazifi E, Sohbatzadeh Lonbar F. A Review of the Therapeutic Effects of Natural Antioxidant Compounds on the Improvement of Autism Spectrum Disorder. Shefaye Khatam 2023; 11 (3) :81-94
URL: http://shefayekhatam.ir/article-1-2389-en.html

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 11, Issue 3 (Summer 2023) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.05 seconds with 45 queries by YEKTAWEB 4657