1. Souto-Maior FN, Fonsêca DVd, Salgado PRR, Monte LdO, de Sousa DP, de Almeida RN. Antinociceptive and anticonvulsant effects of the monoterpene linalool oxide. Pharmaceutical biology. 2017;55(1):63-7. [DOI:10.1080/13880209.2016.1228682]

2. de Sousa DP, Nóbrega FF, Santos CC, de Almeida RN. Anticonvulsant activity of the linalool enantiomers and racemate: investigation of chiral influence. Natural Product Communications. 2010;5(12):1934578X1000501201. [DOI:10.1177/1934578X1000501201]

3. Ferraz CA, Leferink NG, Kosov I, Scrutton NS. Isopentenol utilization pathway for the production of linalool in Escherichia coli using an improved bacterial linalool/nerolidol synthase. ChemBioChem. 2021;22(13):2325-34. [DOI:10.1002/cbic.202100110]

4. Hirano N, Sakamoto K. Linalool odor stimulation improves heat stress tolerance and decreases fat accumulation in nematodes. Bioscience, biotechnology, and biochemistry. 2019;83(1):148-54. [DOI:10.1080/09168451.2018.1518699]

5. Mohamed ME, Abduldaium YS, Younis NS. Ameliorative effect of linalool in cisplatin-induced nephrotoxicity: the role of HMGB1/TLR4/NF-κB and Nrf2/HO1 pathways. Biomolecules. 2020;10(11):1488. [DOI:10.3390/biom10111488]

6. Aprotosoaie AC, Hăncianu M, Costache II, Miron A. Linalool: a review on a key odorant molecule with valuable biological properties. Flavour and fragrance journal. 2014;29(4):193-219. [DOI:10.1002/ffj.3197]

7. Barrera-Sandoval AM, Osorio E, Cardona-Gómez GP. Microglial-targeting induced by intranasal linalool during neurological protection postischemia. European Journal of Pharmacology. 2019;857:172420. [DOI:10.1016/j.ejphar.2019.172420]

8. Sabogal-Guáqueta AM, Posada-Duque R, Cortes NC, Arias-Londoño JD, Cardona-Gómez GP. Changes in the hippocampal and peripheral phospholipid profiles are associated with neurodegeneration hallmarks in a long-term global cerebral ischemia model: Attenuation by Linalool. Neuropharmacology. 2018;135:555-71. [DOI:10.1016/j.neuropharm.2018.04.015]

9. Bappi MH, Prottay AAS, Kamli H, Sonia FA, Mia MN, Akbor MS, et al. Quercetin antagonizes the sedative effects of linalool, possibly through the GABAergic interaction pathway. Molecules. 2023;28(14):5616. [DOI:10.3390/molecules28145616]

10. Ghadiri T, Azarfarin M, Namvar G, Samnia Z. Underlying Mechanisms of Neuroprotective Actions of Klotho Against Cognitive Impairment in Neurodegenerative Diseases. The Neuroscience Journal of Shefaye Khatam. 2024;12(1):1-17. [DOI:10.61186/shefa.12.1.94]

11. Soltani Zangbar H, Ghadiri T, Seyedi Vafaee M, Ebrahimi Kalan A, Fallahi S, Ghorbani M, et al. Theta oscillations through hippocampal/prefrontal pathway: importance in cognitive performances. Brain connectivity. 2020;10(4):157-69. [DOI:10.1089/brain.2019.0733]

12. Caputo L, Piccialli I, Ciccone R, de Caprariis P, Massa A, De Feo V, et al. Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid‐β neurotoxicity. Phytotherapy research. 2021;35(1):486-93. [DOI:10.1002/ptr.6827]

13. Yuan C, Shin M, Park Y, Choi B, Jang S, Lim C, et al. Linalool alleviates aβ42-induced neurodegeneration via suppressing ros production and inflammation in fly and rat models of alzheimer's disease. Oxidative Medicine and Cellular Longevity. 2021;2021. [DOI:10.1155/2021/8887716]

14. Xu P, Wang K, Lu C, Dong L, Gao L, Yan M, et al. Protective effects of linalool against amyloid beta-induced cognitive deficits and damages in mice. Life Sciences. 2017;174:21-7. [DOI:10.1016/j.lfs.2017.02.010]

15. Sabogal-Guáqueta AM, Osorio E, Cardona-Gómez GP. Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice. Neuropharmacology. 2016;102:111-20. [DOI:10.1016/j.neuropharm.2015.11.002]

16. Shahverdi M, Sourani Z, Sargolzaie M, Modarres Mousavi M, Shirian S. An Investigation into the Effects of Water-and Fat-Soluble Vitamins in Alzheimer's and Parkinson's Diseases. The Neuroscience Journal of Shefaye Khatam. 2023;11(3):95-109. [DOI:10.61186/shefa.11.3.95]

17. MODARRES MSM, Ghaemi A, GHADIRI T, MOHAMMAD SS. Application of patient-specific induced Pluripotent Stem cells produced by somatic cells reprogramming for treatment of neurodegenerative diseases. 2013.

18. Mączka W, Duda-Madej A, Grabarczyk M, Wińska K. Natural compounds in the battle against microorganisms-linalool. Molecules. 2022;27(20):6928. [DOI:10.3390/molecules27206928]

19. de Lucena JD, Gadelha-Filho CVJ, da Costa RO, de Araújo DP, Lima FAV, Neves KRT, et al. L-linalool exerts a neuroprotective action on hemiparkinsonian rats. Naunyn-Schmiedeberg's Archives of Pharmacology. 2020;393:1077-88. [DOI:10.1007/s00210-019-01793-1]

20. Asadi A, Abdolmaleki A. New Drugs and their Mechanism in the Treatment of Epilepsy. The Neuroscience Journal of Shefaye Khatam. 2022;10(2):104-10. [DOI:10.61186/shefa.10.2.104]

21. Azanchi T, Shafaroodi H, Asgarpanah J. Anticonvulsant activity of Citrus aurantium blossom essential oil (neroli): involvment of the GABAergic system. Natural product communications. 2014;9(11):1615-8.

22. Vatanparast J, Bazleh S, Janahmadi M. The effects of linalool on the excitability of central neurons of snail Caucasotachea atrolabiata. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2017;192:33-9. [DOI:10.1016/j.cbpc.2016.12.004]

23. Silva Brum L, Elisabetsky E, Souza D. Effects of linalool on [3H] MK801 and [3H] muscimol binding in mouse cortical membranes. Phytotherapy Research. 2001;15(5):422-5. [DOI:10.1002/ptr.973]

24. López V, Nielsen B, Solas M, Ramírez MJ, Jäger AK. Exploring pharmacological mechanisms of lavender (Lavandula angustifolia) essential oil on central nervous system targets. Frontiers in pharmacology. 2017;8:280. [DOI:10.3389/fphar.2017.00280]

25. Elisabetsky E, Brum LS, Souza D. Anticonvulsant properties of linalool in glutamate-related seizure models. Phytomedicine. 1999;6(2):107-13. [DOI:10.1016/S0944-7113(99)80044-0]

26. Elisabetsky E, Marschner J, Onofre Souza D. Effects of linalool on glutamatergic system in the rat cerebral cortex. Neurochemical research. 1995;20:461-5. [DOI:10.1007/BF00973103]

27. Hosseini-Zare MS, Salehi F, Seyedi SY, Azami K, Ghadiri T, Mobasseri M, et al. Effects of pentoxifylline and H-89 on epileptogenic activity of bucladesine in pentylenetetrazol-treated mice. European journal of pharmacology. 2011;670(2-3):464-70. [DOI:10.1016/j.ejphar.2011.09.026]

28. Sampaio LdFS, Maia JGS, de Parijós AM, de Souza RZ, Barata LES. Linalool from rosewood (Aniba rosaeodora Ducke) oil inhibits adenylate cyclase in the retina, contributing to understanding its biological activity. Phytotherapy Research. 2012;26(1):73-7. [DOI:10.1002/ptr.3518]

29. Skalicka-Woźniak K, Walasek M, Aljarba TM, Stapleton P, Gibbons S, Xiao J, et al. The anticonvulsant and anti-plasmid conjugation potential of Thymus vulgaris chemistry: An in vivo murine and in vitro study. Food and chemical toxicology. 2018;120:472-8. [DOI:10.1016/j.fct.2018.07.045]

30. Silva Brum L, Emanuelli T, Souza D, Elisabetsky E. Effects of linalool on glutamate release and uptake in mouse cortical synaptosomes. Neurochemical Research. 2001;26:191-4. [DOI:10.1023/A:1010904214482]

31. Nuzzo D, Scordino M, Scurria A, Giardina C, Giordano F, Meneguzzo F, et al. Protective, antioxidant and antiproliferative activity of grapefruit integropectin on SH-SY5Y cells. International Journal of Molecular Sciences. 2021;22(17):9368. [DOI:10.3390/ijms22179368]

32. Hosseini A, Pourheidar E, Rajabian A, Asadpour E, Hosseinzadeh H, Sadeghnia HR. Linalool attenuated ischemic injury in PC12 cells through inhibition of caspase‐3 and caspase‐9 during apoptosis. Food Science & Nutrition. 2023;11(1):249-60. [DOI:10.1002/fsn3.3057]

33. Farhadi Maghadam B. Neuroprotective Effect of Alpha-Pinene on Focal Cerebral Ischemia in Rats. The Neuroscience Journal of Shefaye Khatam. 2022;10(3):37-47. [DOI:10.52547/shefa.10.3.37]

34. Sabogal-Guáqueta AM, Hobbie F, Keerthi A, Oun A, Kortholt A, Boddeke E, et al. Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity. Biomedicine & Pharmacotherapy. 2019;118:109295. [DOI:10.1016/j.biopha.2019.109295]

35. Coelho V, Mazzardo-Martins L, Martins DF, Santos ARS, da Silva Brum LF, Picada JN, et al. Neurobehavioral and genotoxic evaluation of (−)-linalool in mice. Journal of natural medicines. 2013;67:876-80. [DOI:10.1007/s11418-013-0751-6]

36. Alinejad B, Ghorbani A, Sadeghnia HR. Effects of combinations of curcumin, linalool, rutin, safranal, and thymoquinone on glucose/serum deprivation-induced cell death. Avicenna journal of phytomedicine. 2013;3(4):321.

37. Li Y, Lv O, Zhou F, Li Q, Wu Z, Zheng Y. Linalool inhibits LPS-induced inflammation in BV2 microglia cells by activating Nrf2. Neurochemical research. 2015;40:1520-5. [DOI:10.1007/s11064-015-1629-7]

38. Hansson E, Werner T, Björklund U, Skiöldebrand E. Therapeutic innovation: inflammatory-reactive astrocytes as targets of inflammation. IBRO reports. 2016;1:1-9. [DOI:10.1016/j.ibror.2016.06.001]

39. Han HD, Cho Y-J, Cho SK, Byeon Y, Jeon HN, Kim H-S, et al. Linalool-incorporated nanoparticles as a novel anticancer agent for epithelial ovarian carcinoma. Molecular cancer therapeutics. 2016;15(4):618-27. [DOI:10.1158/1535-7163.MCT-15-0733-T]

40. Machado TQ, Da Fonseca AC, Duarte A, Robbs BK, De Sousa DP. A narrative review of the antitumor activity of monoterpenes from essential oils: An update. BioMed Research International. 2022;2022. [DOI:10.1155/2022/6317201]

41. Jana S, Patra K, Sarkar S, Jana J, Mukherjee G, Bhattacharjee S, et al. Antitumorigenic potential of linalool is accompanied by modulation of oxidative stress: an in vivo study in sarcoma-180 solid tumor model. Nutrition and cancer. 2014;66(5):835-48. [DOI:10.1080/01635581.2014.904906]

42. Karami Fath M, Karimfar N, Fazlollahpour Naghibi A, Shafa S, Ghasemi Shiran M, Ataei M, et al. Revisiting characteristics of oncogenic extrachromosomal DNA as mobile enhancers on neuroblastoma and glioma cancers. Cancer Cell International. 2022;22(1):200. [DOI:10.1186/s12935-022-02617-8]

43. Heydarian S. Drug Nanocarriers as a Potential Therapeutic Strategy in Glioblastoma Multiforme. The Neuroscience Journal of Shefaye Khatam. 2023;11(3):110-26. [DOI:10.61186/shefa.11.3.110]

44. Cheng Y, Dai C, Zhang J. SIRT3-SOD2-ROS pathway is involved in linalool-induced glioma cell apoptotic death. Acta Biochimica Polonica. 2017;64(2):343-50. [DOI:10.18388/abp.2016_1438]

45. Nematgorgani S, Gholi Z, Jahromi SR, Togha M, Karimzadeh F. The effect of vitamins b on improving the symptoms of migraine: An overview. Neuroscience Journal of Shefaye Khatam. 2020;8(2):119-29. [DOI:10.29252/shefa.8.2.119]

46. Yuan R, Shi Y, Zhang J, Hu Q, Wei X, Luo C, et al. Study on the chemical constituents and anti-migraine activity of supercritical CO2 extracts of Zanthoxylum schinifolium. Frontiers in Pharmacology. 2021;12:744035. [DOI:10.3389/fphar.2021.744035]

47. Tashiro S, Yamaguchi R, Ishikawa S, Sakurai T, Kajiya K, Kanmura Y, et al. Odour-induced analgesia mediated by hypothalamic orexin neurons in mice. Scientific reports. 2016;6(1):37129. [DOI:10.1038/srep37129]

48. Lee BK, Jung AN, Jung Y-S. Linalool ameliorates memory loss and behavioral impairment induced by REM-sleep deprivation through the serotonergic pathway. Biomolecules & Therapeutics. 2018;26(4):368. [DOI:10.4062/biomolther.2018.081]

49. Dos Santos ÉRQ, Maia JGS, Fontes-Júnior EA, Maia CdSF. Linalool as a therapeutic and medicinal tool in depression treatment: A review. Current Neuropharmacology. 2022;20(6):1073. [DOI:10.2174/1570159X19666210920094504]

50. Guzmán-Gutiérrez S, Gómez-Cansino R, García-Zebadúa J, Jiménez-Pérez N, Reyes-Chilpa R. Antidepressant activity of Litsea glaucescens essential oil: Identification of β-pinene and linalool as active principles. Journal of ethnopharmacology. 2012;143(2):673-9. [DOI:10.1016/j.jep.2012.07.026]

51. Caputo L, Reguilon MD, Mińarro J, De Feo V, Rodriguez-Arias M. Lavandula angustifolia essential oil and linalool counteract social aversion induced by social defeat. Molecules. 2018;23(10):2694. [DOI:10.3390/molecules23102694]

52. Guzmán-Gutiérrez SL, Bonilla-Jaime H, Gómez-Cansino R, Reyes-Chilpa R. Linalool and β-pinene exert their antidepressant-like activity through the monoaminergic pathway. Life sciences. 2015;128:24-9. [DOI:10.1016/j.lfs.2015.02.021]

53. Chang H-T, Chang M-L, Chen Y-T, Chang S-T, Hsu F-L, Wu C-C, et al. Evaluation of motor coordination and antidepressant activities of Cinnamomum osmophloeum ct. linalool leaf oil in rodent model. Molecules. 2021;26(10):3037. [DOI:10.3390/molecules26103037]

54. Lu Z, Zhang T, Wang X, Wang J, Shen J, Xiao Z, et al. Zwitterionic polymer-based nanoparticles encapsulated with linalool for regulating central nervous system. ACS Biomaterials Science & Engineering. 2019;6(1):442-9. [DOI:10.1021/acsbiomaterials.9b01451]

55. Wang X, Lu Z, Shen J, Niu Y, Xiao Z, Chen L, et al. Nano-fragrance with pH-sensitive release property for improvement of central nervous system. Journal of Biomedical Nanotechnology. 2020;16(2):193-200. [DOI:10.1166/jbn.2020.2873]

56. Deng L, Shi AM, Wang Q. Sedative-hypnotic and anxiolytic effects and the mechanism of action of aqueous extracts of peanut stems and leaves in mice. Journal of the Science of Food and Agriculture. 2018;98(13):4885-94. [DOI:10.1002/jsfa.9020]

57. Zu X, Zhang Z, Xiong G, Liao T, Qiao Y, Li Y, et al. Sedative effects of Arachis hypogaea L. stem and leaf extracts on sleep‑deprived rats. Experimental and Therapeutic Medicine. 2013;6(2):601-5. [DOI:10.3892/etm.2013.1182]

58. Linck VdM, da Silva AL, Figueiró M, Caramao EB, Moreno PRH, Elisabetsky E. Effects of inhaled Linalool in anxiety, social interaction and aggressive behavior in mice. Phytomedicine. 2010;17(8-9):679-83. [DOI:10.1016/j.phymed.2009.10.002]

59. Souto-Maior FN, de Carvalho FL, de Morais LCSL, Netto SM, de Sousa DP, de Almeida RN. Anxiolytic-like effects of inhaled linalool oxide in experimental mouse anxiety models. Pharmacology Biochemistry and Behavior. 2011;100(2):259-63. [DOI:10.1016/j.pbb.2011.08.029]

60. Yoshida K, Yamamoto N, Fujiwara S, Kamei A, Abe K, Nakamura A. Inhalation of a racemic mixture (R, S)-linalool by rats experiencing restraint stress alters neuropeptide and MHC class I gene expression in the hypothalamus. Neuroscience Letters. 2017;653:314-9. [DOI:10.1016/j.neulet.2017.05.046]

61. Cheng B-H, Sheen L-Y, Chang S-T. Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice. Journal of traditional and complementary medicine. 2015;5(1):27-34. [DOI:10.1016/j.jtcme.2014.10.007]

62. Igarashi T. Physical and psychologic effects of aromatherapy inhalation on pregnant women: a randomized controlled trial. The journal of alternative and complementary medicine. 2013;19(10):805-10. [DOI:10.1089/acm.2012.0103]

63. Kitajima M, Miura M, Nanashima N, Tomisawa T, Takamagi S, Fujioka M, et al. Psychological and Antibacterial Effects of Footbath Using the Lindera umbellata Essential Oil. Molecules. 2021;26(17):5128. [DOI:10.3390/molecules26175128]

64. Okuyama S, Sawasaki E, Yokogoshi H. Conductor compounds of phenylpentane in Mycoleptodonoides aitchisonii mycelium enhance the release of dopamine from rat brain striatum slices. Nutritional neuroscience. 2004;7(2):107-11. [DOI:10.1080/10284150410001710429]

65. Ghadiri T, Modarres Mousavi M, Alipour F, Mohammad Sadeghi S. Cellular and Molecular Pathways of Learning and memory. The Neuroscience Journal of Shefaye Khatam. 2014;2(2):81-8. [DOI:10.18869/acadpub.shefa.2.2.81]

66. Hajali V, Sheibani V, Ghazvini H, Ghadiri T, Valizadeh T, Saadati H, et al. Effect of castration on the susceptibility of male rats to the sleep deprivation-induced impairment of behavioral and synaptic plasticity. Neurobiology of learning and memory. 2015;123:140-8. [DOI:10.1016/j.nlm.2015.05.008]

67. Zhong Y, Zheng Q, Hu P, Huang X, Yang M, Ren G, et al. Sedative and hypnotic effects of compound Anshen essential oil inhalation for insomnia. BMC complementary and alternative medicine. 2019;19:1-11. [DOI:10.1186/s12906-019-2732-0]

68. Rouyar A, Party V, Prešern J, Blejec A, Renou M. A general odorant background affects the coding of pheromone stimulus intermittency in specialist olfactory receptor neurones. PLoS One. 2011;6(10):e26443. [DOI:10.1371/journal.pone.0026443]

69. Yunusoğlu O. Rewarding effect of ethanol-induced conditioned place preference in mice: Effect of the monoterpenoid linalool. Alcohol. 2022;98:55-63. [DOI:10.1016/j.alcohol.2021.11.003]

70. Narusuye K, Kawai F, Matsuzaki K, Miyachi E. Linalool suppresses voltage-gated currents in sensory neurons and cerebellar Purkinje cells. Journal of neural transmission. 2005;112:193-203. [DOI:10.1007/s00702-004-0187-y]