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:: Volume 12, Issue 3 (Summer 2024) ::
Shefaye Khatam 2024, 12(3): 55-63 Back to browse issues page
Comparison of twelve weeks of endurance and resistance exercise on the levels of acetylcholine and interleukin-1 beta in Alzheimer's male rats.
Azadeh Naderi , Abbas Saremi * , Mohammad reza Afarinesh khaki
Department of Sports Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran , a-saremi@araku.ac.ir
Abstract:   (596 Views)
Introduction: Alzheimer’s disease (AD) is the leading cause of dementia, and there is growing evidence that exercise programs may help improve some symptoms of the disease. This study aimed to compare the effects of endurance and resistance training on acetylcholine and interleukin-1 beta levels in AD-model male rats. Materials and Methods: Twenty-eight male Wistar rats were selected and randomly assigned to four groups: healthy control, AD control, AD + resistance training, and AD + endurance training. AD was induced using an 8 mg dose of trimethyltin chloride. The endurance training consisted of swimming in water at 30–33°C, five days a week, for sessions gradually increasing from 15 to 60 minutes over 12 weeks. Resistance training involved rats climbing a one-meter ladder with weights attached to their tails, consisting of 26 steps at an 85-degree incline, also performed five days a week for twelve weeks. After the exercise period, blood levels of acetylcholine and interleukin-1 beta were measured using the ELISA method. Results: The results showed that acetylcholine levels in the AD control group were significantly lower than in both the AD + endurance group and the healthy control group. Following the exercise intervention, interleukin-1 beta levels in the healthy control group were significantly lower than in the AD control, AD + resistance, and AD + endurance groups. However, there was no significant difference in interleukin-1 beta levels between the endurance and resistance training groups. Conclusion: These findings suggest that exercise may be beneficial in reducing inflammation associated with AD, with endurance training showing slightly greater effectiveness than resistance training in this context. This suggests that specific types of exercise might play a role in managing the inflammatory state of AD, potentially offering therapeutic benefits.
 
Keywords: Inflammation, Oxidative Stress, Dementia
Full-Text [PDF 679 kb]   (205 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Neuropathology
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Naderi A, Saremi A, Afarinesh khaki M R. Comparison of twelve weeks of endurance and resistance exercise on the levels of acetylcholine and interleukin-1 beta in Alzheimer's male rats.. Shefaye Khatam 2024; 12 (3) :55-63
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Volume 12, Issue 3 (Summer 2024) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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