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:: Volume 8, Issue 2 (Spring 2020) ::
Shefaye Khatam 2020, 8(2): 107-118 Back to browse issues page
Pathogenic and Therapeutic Role of Micrornas in Glioblastoma Multiforme
Maliheh Babazadeh , Mohammad Reza Zolfaghary , Sadegh Shirian , Amir Ghaemi *
Department of Influenza and other Respiratory Viruses, Pasteur Institute of Iran, Tehran, Iran , ghaem_amir@yahoo.com
Abstract:   (3265 Views)
Introduction: Glioblastoma multiforme (GBM) is a severe type of brain tumors with very poor prognosis and a median survival time of about 15 months. To identify new biomarkers and therapeutic approaches, novel methods are crucial to treat GBM, based on the biological and molecular nature of these tumors. Recently, microRNAs (miRNAs) have been extensively used with the aim of developing accurate molecular therapies, due to their emerging role in the regulation of cancer-related genes. miRNAs, a class of small non-coding RNA species, have vital roles across various biological processes, which may serve as diagnostic and prognostic tools in GBM. Conclusion: This review indicated that miRNAs signatures could be used for developing new molecular therapies to enhance the survival of GBM patients. On the other hand, miRNAs regulate a wide range of cellular functions, allowing them to modulate many pathways critical to GBM progression, including proliferation, cell death, metastasis, angiogenesis, and drug resistance.
Keywords: Glioblastoma, MicroRNAs, Cell Death
Full-Text [PDF 1053 kb]   (1389 Downloads)    
Type of Study: Review --- Open Access, CC-BY-NC | Subject: Basic research in Neuroscience
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Babazadeh M, Zolfaghary M R, Shirian S, Ghaemi A. Pathogenic and Therapeutic Role of Micrornas in Glioblastoma Multiforme. Shefaye Khatam 2020; 8 (2) :107-118
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Volume 8, Issue 2 (Spring 2020) Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
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