[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
Main Menu
Home::
Journal Information::
Articles Archive::
Guide for Authors::
For Reviewers::
Ethical Statements::
Registration::
Site Facilities::
Contact us::
::
Indexed by
     
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Copyright Policies

 

AWT IMAGE

 

..
Open Access Policy

This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

..
:: Articles In Press ::
Back to the articles list Back to browse issues page
Gender Bias in Autism Assessment: A Content Analysis of Gender-Linked Behaviors in Items of ADOS-2, GARS-3, and CARS2-ST
Saeed Hassan Zade , Sahar Zeynali *
Department of Psychology, Faculty of Psychology and Educational Sciences, University of Tehran, Tehran, Iran , saharzeynali@ut.ac.ir
Abstract:   (5 Views)
Introduction: Autism spectrum disorder (ASD) is one of the most common neurodevelopmental pathological conditions, with epidemiological data consistently indicating higher prevalence rates in boys than in girls. It remains unclear whether this sex difference reflects a genuine biologically based disparity or whether commonly used diagnostic instruments have been developed primarily around more overt and stereotypically male behavioral profiles. Existing evidence in this area remains limited and heterogeneous. The present study aimed to examine gender-related imbalance in the items of widely used ASD screening and diagnostic scales. Materials and Methods: Items from the Autism Diagnostic Observation Schedule–Second Edition (ADOS-2), the Gilliam Autism Rating Scale–Third Edition (GARS-3), and the Childhood Autism Rating Scale, Second Edition–Standard Version (CARS2-ST) were analyzed using a directed qualitative content analysis approach. In total, 91 items were examined through three cycles of open, axial, and selective coding to identify how social, emotional, and communicative behaviors are represented in each scale with respect to gender-related differences. Results: The findings indicated that, despite structural differences, all three instruments contained identifiable patterns of gender-related imbalance at the item-content level. This imbalance was primarily reflected in an emphasis on overt behaviors and patterns more frequently reported in boys in the research literature. Limited attention to social camouflaging, imitative coping strategies, and the presence of subtle or controlled behaviors observed in some autistic girls also emerged as an important theme. Cross-scale comparisons showed that the ADOS-2 appears more vulnerable to the masking of symptoms behind apparently typical behaviors, the CARS2-ST is more influenced by clinical judgments shaped by gendered social norms, and the GARS-3 places greater emphasis on more overt and male-typical presentations of restricted and repetitive behaviors. Examination of the gender composition of the norming samples further revealed that boys outnumbered girls by approximately 3:1 to 4:1 across all three instruments. Conclusion: Taken together, these findings, without rejecting biological or neuropsychological explanations for sex differences in autism prevalence, suggest that the content and norming characteristics of assessment instruments may contribute to the lower identification of girls, particularly those who use camouflaging and adaptive social strategies. Revising item content, attending to different presentations of autism in girls and boys, and developing gender-informed norms for future diagnostic instruments may warrant further consideration.
 
Keywords: Autism Spectrum Disorder, Sex Differences, Psychometrics, Diagnosis, Social Interaction
Full-Text [PDF 1623 kb]   (3 Downloads)    
Type of Study: Research --- Open Access, CC-BY-NC | Subject: Psycology
References
1. Loomes R, Hull L, Mandy WPL. What is the male-to-female ratio in autism spectrum disorder? A systematic review and meta-analysis. Journal of the American Academy of Child & Adolescent Psychiatry. 2017; 56(6): 466-74. [DOI:10.1016/j.jaac.2017.03.013]
2. Baron-Cohen S. The extreme male brain theory of autism. Trends in Cognitive Sciences. 2002; 6(6): 248-54. [DOI:10.1016/S1364-6613(02)01904-6]
3. Baron-Cohen S. Empathizing and systemizing in males, females and autism: A test of the neural competition theory. Decety J, editor. Empathy and related concepts in health. Oxford: Oxford University Press. 2011; p. 3-17.
4. Baron-Cohen S, Wheelwright S. The empathy quotient: An investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. Baron-Cohen S, Tager-Flusberg H, Cohen DJ, editors. Understanding other minds: Perspectives from developmental cognitive neuroscience. 2nd ed. Cambridge: Cambridge University Press. 2004; p. 583-606. [DOI:10.1023/B:JADD.0000022607.19833.00]
5. Auyeung B, Baron-Cohen S, Ashwin E, Knickmeyer R, Taylor K, Hackett G. Fetal testosterone and autistic traits. British Journal of Psychology. 2009; 100: 1-22. [DOI:10.1348/000712608X311731]
6. Shalev I, Warrier V, Greenberg DM, Smith P, Allison C, Baron-Cohen S, et al. Reexamining empathy in autism: Empathic disequilibrium as a novel predictor of autism diagnosis and autistic traits. Autism Research. 2022; 15(10): 1917-28. [DOI:10.1002/aur.2794]
7. Hull L, Mandy W, Lai MC, Baron-Cohen S, Allison C, Smith P, et al. Development and validation of the Camouflaging Autistic Traits Questionnaire (CAT-Q). Journal of Autism and Developmental Disorders. 2019; 49(3): 819-33. [DOI:10.1007/s10803-018-3792-6]
8. Tubío-Fungueiriño M, Cruz S, Sampaio A, Carracedo A, Fernández-Prieto M. Social camouflaging in females with autism spectrum disorder: A systematic review. Journal of Autism and Developmental Disorders. 2021; 51(7): 2190-99. [DOI:10.1007/s10803-020-04695-x]
9. Curd J, Nguyễn TST. "I was always on the outside, watching quietly": Autistic women reflect on school experiences. Humanities and Social Sciences Communications. 2024; 11: 1148. [DOI:10.1057/s41599-024-03632-y]
10. Dell'Osso L, Cremone IM, Carpita B, Fagiolini A, Massimetti G, Muti D, et al. Autism spectrum in borderline personality disorder. CNS Spectrums. 2021; 26(2): 132-43.
11. Ventola P, Kleinman J, Pandey J, Barton M, Allen S, Green J, et al. Agreement among three diagnostic instruments for autism spectrum disorders in toddlers. Journal of Autism and Developmental Disorders. 2006; 36(7): 839-47. [DOI:10.1007/s10803-006-0128-8]
12. Tsirgiotis JM, Young RL, Weber N. Sex/gender differences in CARS2 and GARS-3 item scores: evidence of phenotypic differences between males and females with ASD. J Autism Dev Disord. 2022; 52(9): 3958-3976. [DOI:10.1007/s10803-021-05286-0]
13. Rea HM, Øien RA, Shic F, Webb SJ, Ratto AB. Sex differences on the ADOS-2: Item-level analysis of diagnostic sensitivity. Journal of Autism and Developmental Disorders. 2023; 53(7): 2878-90. [DOI:10.1007/s10803-022-05566-3]
14. Tierney S, Burns J, Kilbey E. Looking behind the mask: Social coping strategies of girls on the autistic spectrum. Research in Autism Spectrum Disorders. 2016; 23: 73-83. [DOI:10.1016/j.rasd.2015.11.013]
15. Lai MC, Lombardo MV, Auyeung B, Chakrabarti B, Baron-Cohen S. Sex/gender differences and autism: Setting the scene for future research. Journal of the American Academy of Child & Adolescent Psychiatry. 2015; 54(1): 11-24. [DOI:10.1016/j.jaac.2014.10.003]
16. Hull L, Lai MC, Baron-Cohen S, Allison C, Smith P, Petrides KV, et al. Gender differences in self-reported camouflaging in autistic and non-autistic adults. Autism. 2020; 24(2): 351-63. [DOI:10.1177/1362361319864804]
17. Dean M, Harwood R, Kasari C. The art of camouflage: Gender differences in the social behaviors of girls and boys with autism spectrum disorder. Autism. 2017; 21(6): 678-89. [DOI:10.1177/1362361316671845]
18. Lockwood Estrin G, Milner V, Spain D, Happé F, Colvert E. Barriers to autism spectrum disorder diagnosis for young women and girls: A systematic review. Review Journal of Autism and Developmental Disorders. 2021; 8: 454-70. [DOI:10.1007/s40489-020-00225-8]
19. Sedgewick F, Hill V, Pellicano E. Girls and autism: Differences in social play behaviours. Autism. 2019; 23(4): 954-65. [DOI:10.1177/1362361318794930]
20. Livingston LA, Happé F. Conceptualising compensation in neurodevelopmental disorders: Reflections from autism spectrum disorder. Neuroscience & Biobehavioral Reviews. 2017; 80: 729-42. [DOI:10.1016/j.neubiorev.2017.06.005]
21. Frazier TW, Youngstrom EA, Sinclair L, Kubu C, Law P, Rezai A, et al. Gender differences in the factor structure of the Social Responsiveness Scale. Autism. 2014; 18(4): 342-53.
22. Parrish-Morris J, Mahajan N, Kissel S, Pandey J, Constantino JN, Schultz RT, et al. Measurement invariance of the Autism Impact Measure across sex. Autism Research. 2022; 15: 1834-46.
23. Hoekstra RA, Vinkhuyzen AAE, Wheelwright S, Bartels M, Boomsma DI, Baron-Cohen S, et al. The construction and validation of short forms of the Autism Spectrum Quotient (AQ). Personality and Individual Differences. 2011; 51(3): 234-38. [DOI:10.1037/t29402-000]
24. Murray AL, Booth T, McKenzie K, Kuenssberg R. Do the Autism Spectrum Quotient (AQ) and the Autism Spectrum Quotient-Short Form (AQ-S) measure the same construct? Personality and Individual Differences. 2014; 56: 46-51. [DOI:10.1016/j.paid.2013.07.232]
25. Ritvo RA, Ritvo ER, Guthrie D, Ritvo MJ, Hufnagel DH, McMahon W, et al. The Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS-R): A scale to assist the diagnosis of autism spectrum disorder in adults. Journal of Autism and Developmental Disorders. 2011; 41: 1076-89. [DOI:10.1007/s10803-010-1133-5]
26. Eriksson JM, Andersen LM, Bejerot S. RAADS-14 Screen: A brief screening tool for autism spectrum disorder in adults. Psychiatry Research. 2013; 210(2): 439-45. [DOI:10.1186/2040-2392-4-49]
27. Gorji R, Hassanzadeh S, Ghasemzadeh S, Qolamali Lavasani M. Sensitivity and specificity Gilliam Autism Rating Scale (GARS) in diagnosis autism spectrum disorders: systematic review. The Neuroscience Journal of Shefaye Khatam. 2020; 8(4): 80-89. [DOI:10.29252/shefa.8.4.80]
28. Akbari Bayatiani Z. Autism spectrum disorder from diagnosis to treatment. The Neuroscience Journal of Shefaye Khatam. 2018; 6(4): 93-101. [DOI:10.29252/shefa.6.4.93]
29. Saeedi C. Investigation of dysfunction in the neural systems underlying social perception, action observation and theory of mind in autism spectrum disorders. The Neuroscience Journal of Shefaye Khatam. 2018; 6(2): 82-93. [DOI:10.29252/shefa.6.2.82]
30. Seyed Fakhari N, Ghaderi F. Analyzing behavioral markers of autistic children using eye tracking data. The Neuroscience Journal of Shefaye Khatam. 2019; 7(4): 79-88. [DOI:10.29252/shefa.7.4.79]
31. Mahmodi H, Ebrahimi B, Sabaghi A. The relationship between the persistence of early reflections and the severity of hyperactivity and autism in children. The Neuroscience Journal of Shefaye Khatam. 2022; 10(2): 82-90. [DOI:10.61186/shefa.10.2.82]
32. Minaei A, Nazeri S. Psychometric properties of the Gilliam Autism Rating Scale-Third Edition (GARS-3) in individuals with autism: A pilot study. Journal of Exceptional Children. 2018; 18(2): 113-22.
33. Samadi SA, Mahmoodizadeh A, Foladgar M, Bakhshalizadeh Moradi S, Lotfi B, McConkey R. The Childhood Autism Rating Scale Second Edition (CARS2) and its applicability in an Iranian sample. Autism Research. 2025; 18(3): 541-52. [DOI:10.1002/aur.3309]
34. Randall M, Egberts KJ, Samtani A, Scholten RJPM, Hooft L, Livingstone N, et al. Diagnostic tests for autism spectrum disorder (ASD) in preschool children. Cochrane Database of Systematic Reviews. 2018; 2018(7): CD009044. [DOI:10.1002/14651858.CD009044.pub2]
35. Hsieh HF, Shannon SE. Three approaches to qualitative content analysis. Qualitative Health Research. 2005; 15(9): 1277-88. [DOI:10.1177/1049732305276687]
36. Assarroudi A, Heshmati Nabavi F, Armat MR, Ebadi A, Vaismoradi M. Directed qualitative content analysis: The description and elaboration of its underpinning methods and data analysis process. Journal of Research in Nursing. 2018; 23(1): 42-55. [DOI:10.1177/1744987117741667]
37. Gilliam JE. Gilliam Autism Rating Scale-Third Edition (GARS-3) Manual. Austin: Pro-Ed Publishing. 2014.
38. Lord C, Rutter M, DiLavore PC, Risi S, Gotham K, Bishop S. Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) Manual. Torrance: Western Psychological Services. 2012.
39. Schopler E, Van Bourgondien ME, Wellman GJ, Love SR. Childhood Autism Rating Scale-Second Edition (CARS-2) Manual. Torrance: Western Psychological Services. 2010.
40. Bargiela S, Steward R, Happé F. The experiences of late-diagnosed women with autism spectrum conditions: An investigation of the female autism phenotype. Journal of Autism and Developmental Disorders. 2016; 46(10): 3281-94. [DOI:10.1007/s10803-016-2872-8]


XML   Persian Abstract   Print



Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Back to the articles list Back to browse issues page
مجله علوم اعصاب شفای خاتم The Neuroscience Journal of Shefaye Khatam
Persian site map - English site map - Created in 0.16 seconds with 47 queries by YEKTAWEB 4766